Symbol
Name
ID

Ptprc
protein tyrosine phosphatase receptor type C
MGI:97810

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

hematopoietic system phenotype

increased T cell apoptosis

abnormal granulocyte differentiation

decreased B cell proliferation

decreased T cell proliferation

decreased mast cell degranulation

thymus hypoplasia

decreased thymocyte number

decreased DN4 thymocyte number

increased DN3 thymocyte number

abnormal thymocyte activation

enlarged spleen

spleen hyperplasia

abnormal erythropoiesis

abnormal lymphopoiesis

abnormal B cell differentiation

increased transitional stage B cell number

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell selection

abnormal positive T cell selection

increased double-negative T cell number

abnormal double-positive T cell morphology

decreased double-positive T cell number

arrested T cell differentiation

extramedullary hematopoiesis

abnormal bone marrow cell morphology/development

increased neutrophil cell number

abnormal leukocyte cell number

increased plasmacytoid dendritic cell number

increased dendritic cell number

abnormal B cell number

decreased mature B cell number

decreased B-1a cell number

decreased B-1b cell number

decreased B-2 B cell number

decreased follicular B cell number

decreased memory B cell number

increased B-1 B cell number

increased B-1b cell number

increased plasma cell number

decreased B cell number

increased B cell number

decreased NK cell number

increased NK cell number

abnormal T cell subpopulation ratio

increased central memory CD4-positive, alpha-beta T cell number

decreased effector memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta memory T cell number

decreased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased alpha-beta T cell number

increased alpha-beta T cell number

decreased gamma-delta intraepithelial T cell number

abnormal intraepithelial T cell number

abnormal memory T cell number

decreased memory T cell number

increased memory T cell number

decreased T cell number

absent T cells

decreased single-positive T cell number

increased T cell number

increased single-positive T cell number

decreased leukocyte cell number

abnormal leukocyte morphology

abnormal lymphocyte morphology

abnormal T cell morphology

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal intraepithelial T cell morphology

abnormal osteoclast morphology

increased spleen red pulp amount

increased spleen white pulp amount

abnormal B cell activation

abnormal follicular B cell physiology

increased IgA level

decreased IgE level

increased IgG2a level

abnormal NK cell physiology

abnormal T cell physiology

decreased cytotoxic T cell cytolysis

abnormal T cell activation

abnormal osteoclast physiology

Availability

Mouse Genotype

Ptprc^loc/Ptprc^loc

Ptprc^ltng/Ptprc^ltng

Ptprc^m1Btlr/Ptprc^m1Btlr

Ptprc^m1Smv/Ptprc^m1Smv

Ptprc^m2Btlr/Ptprc^m2Btlr

Ptprc^m3Btlr/Ptprc^m3Btlr

Ptprc^M5Btlr/Ptprc^M5Btlr

Ptprc^M6Btlr/Ptprc^M6Btlr

Ptprc^m7Btlr/Ptprc^m7Btlr

Ptprc^M8Btlr/Ptprc^M8Btlr

Ptprc^M9Btlr/Ptprc^M9Btlr

Ptprc^M10Btlr/Ptprc^M10Btlr

Ptprc^M11Btlr/Ptprc^M11Btlr

Ptprc^m12Btlr/Ptprc^m12Btlr

Ptprc^nim/Ptprc^nim

Ptprc^rain/Ptprc^rain

Ptprc^strm/Ptprc^strm

Ptprc^tm1Holm/Ptprc^tm1Holm

Ptprc^tm1Mak/Ptprc^tm1Mak

Ptprc^tm1Tyb/Ptprc^tm1Tyb

Ptprc^tm1Weis/Ptprc^tm1Weis

Tg(ITGAL-Ptprc)FWcr/Tg(ITGAL-Ptprc)FWcr

Ptprc^ltng/Ptprc^tm1Mak

Ptprc^tm1Weis/Ptprc⁺

Ptprc^m4Btlr/Ptprc^m4Btlr (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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